1.เป็นแค่บทความในFrobes ที่อ้างอิงมาจากเวบไวน์อีกที(ในเวบต้นทางหายไปแล้วอีกต่างหาก)
2.ผมลองค้นไม่เจอบทความนี้ในวารสารการแพทย์ใดๆ รวมทั้งเวบAmerican College of Gastroenterologyที่คุณอ้างถึงด้วย
3.ผมค้นชื่อคนที่พูด ก็ไม่เจองานวิจัยที่เค้าทำซักเปเปอร์
4.บทความตั้งแต่ปี2003แล้ว
สรุปคือความน่าเชื่อถือต่ำมาก ในขณะที่มีงานวิจัยเป้นพันรวมทั้งsystemic review,metaanalysis บอกตรงกันว่าการดื่มalcoholเพิ่มโอกาสเกิดมะเร็งลำไส้
ในคนไข้มะเร็งลำไส้แพทย์จะแนะนำให้งดแอลกอฮอล์ทุกชนิด คุณจะเอาบทความอะไรก็ไม่รู้บทความเดียวาะแนะนำให้เค้าดื่มเพิ่มไม่ได้
ขอบคุณที่เป็นห่วงเพื่อนสมาชิกที่ป่วย ผมก็ห่วงเขาครับ
ผมไม่ทราบเพื่อนสมาชิกที่ห่วงนี่เป็นแพทย์หรือเปล่านะครับ ส่วนตัวผมทำงานวิทยาศาสตร์การแพทย์ให้โรงพยาบาลนพรัตนราชธานี หลายปี ครับ
ก็กูเกิล คำง่าย ๆ red wine and colorectal cancer (ถ้าเสิร์ช alcohol แทน จะพบผลลบเป็นส่วนใหญ่ ครับ ต่างกับ red wine)
1. นี่ครับ ที่คุณหาไม่เจอ
They found that red wine dramatically reduced the risk of colorectal neoplasia* by 68 percent but white wine did not.
*either polyps or cancer
[https://acgcdn.gi.org/wp-content/uploads/2011/07/media-releases-06ACG_Resveratrol.pdf]
2. นี่บทความปี 2019 ครับ สำรวจ CRC 12,110 กรณี
This meta-analysis suggests that any wine consumption was not associated with the risk of CRC. Null associations were shown in men and women for colon and rectal cancer. [https://pubmed.ncbi.nlm.nih.gov/30247171/]
3. อันนี้ Cancer.gov ครับ
The plant secondary compound resveratrol, found in grapes used to make red wine and some other plants, has been investigated for many possible health effects, including cancer prevention. However, researchers have found no association between moderate consumption of red wine and the risk of developing prostate cancer (32) or colorectal cancer (33).
4. หรือบทความปี 2018
During the last decade, numerous studies have revealed that a moderate consumption of wine, as part of a healthy diet, is associated with protective effects against relevant chronic diseases despite its ethanol content and it harmful effects. For several years, numerous epidemiological studies have maintained that a moderate consumption of wine lowered the risks of mortality due to coronary diseases, compared to wine abstinence [1,2]. For example, in France, as compared with other western countries with a fat-containing diet, the strikingly low incidence of coronary heart diseases is partly attributed to the moderate consumption of red wine [3].
A group of selected post-myocardial infarct patients receiving 250 mL/day of red wine for 2 weeks, in comparison to patients receiving water in a controlled environment in the hospital [13]. For the first time in a controlled environment, these results reinforced the idea that a moderate consumption of red wine, even for a short period, associated with a Western prudent diet, improves various blood parameters in the lipid and antioxidative status in patients with previous coronary ischemic accidents.
Other studies tend to show beneficial effects related to wine consumption on the occurrence of degenerative pathologies, for example, age-related macular degeneration (AMD) [14], dementia [15,16,17,18], and cancers [19,20]. Subsequently, various studies have been conducted to determine the effect of different preparations enriched with wine polyphenol or polyphenol grape extracts on various pathologies such as cardiovascular [21,22], ocular [23], inflammatory and age-related degenerative diseases [24,25], and cancers [26,27] (Figure 1).
Moreover, other casecontrol studies have examined the association between wine and the Mediterranean diet, showing a lower risk of colon cancer and certain other cancers, such as urinary tract tumors, compared to other diets [38,39,40].
One study did not find an inverse association between moderate red wine intake and the risk of colorectal cancer [41] or breast cancer [42].
Various reports have demonstrated the anticancer action of red wine polyphenols in animal models. For example, tumoral C26 growth was significantly reduced with red wine polyphenols in BALB/c mice [27]. In this study, red wine extract (RWE) decreased tumor vascularization and the expression of proangiogenic factors including vascular endothelial growth factor (VEGF), metalloproteinases (MMP-2, MMP-9), and cyclo-oxygenase-2 (COX-2) proteins (Figure 2).
Consequently, the effects of wine consumption, particularly in a healthy population, may depend on the composition of the wine or grape polyphenols and their bioavailability [54,55]. Otherwise, dietary polyphenols exert a beneficial effect at a local level (colon) directly, during their passage through the oral cavity and the gastrointestinal tract, and at a systemic level, after being absorbed. Therefore, one of the organs that can be a targeted is the intestine and colon.
[https://www.mdpi.com/2079-9721/6/4/106]
5. หรือวารสารปี 2019
Researchers say people who drink a moderate amount of red wine have better gut health.
[https://www.healthline.com/health-news/red-wine-may-benefit-gut-health#:~:text=Why%20Red%20Wine%20Is%20Better%20Than%20White%20Wine%20for%20Gut%20Health&text=Researchers%20say%20people%20who%20drink,lower%20levels%20of%20bad%20cholesterol.]
6. ถ้าไม่เชื่อวารสาร กลับมาดู pubmed ปี 2015
However, some studies suggest that moderate alcohol consumption may have a protective effect, similar to that seen in cardiovascular disease.
[https://pubmed.ncbi.nlm.nih.gov/26110674/]
7. หรือปี 2010 นี่ครับ
Moderate alcohol consumption was associated with a reduced CRC risk in study populations with greater adherence to a Mediterranean diet, where wine contributed substantially to the alcoholic beverage consumed.
[https://pubmed.ncbi.nlm.nih.gov/20661834/#:~:text=The%20lack%20of%20clear%20association,population%20of%20middle%2Daged%20men.]
8. กลับมาวารสาร ที่อ้างอิงแหล่งแพทย์วารสารการแพทย์หลายแหล่ง
Rich in antioxidants
There are many antioxidant-rich foods and beverages, and wine is one of them.
Antioxidants are compounds that prevent cellular damage caused by inflammation and oxidative stress. Oxidative stress is a condition caused by an imbalance between antioxidants and unstable molecules called free radicals, which can damage your cells (5Trusted Source).
Grapes have high levels of polyphenols, which are antioxidants that have been shown to reduce oxidative stress and inflammation (6Trusted Source).
Because red wine grapes are higher in antioxidants than white grape varieties, drinking red wine may increase your blood antioxidant levels to a greater extent than drinking white (7Trusted Source).
One 2023 meta-analysis concluded that moderate amounts of red wine, in the context of a Mediterranean diet, showed beneficial effects on the oxidative status of healthy subjects due to the increased expression of antioxidant enzymes (8Trusted Source).
Higher antioxidant status is associated with a decreased risk of disease (9Trusted Source).
May help combat inflammation
Wine contains compounds that have anti-inflammatory properties.
Chronic inflammation is harmful and may increase the risk of conditions such as heart disease, autoimmune disorders, and certain cancers. Therefore, its best to prevent this type of inflammation as much as possible (10Trusted Source).
Chronic inflammation can be reduced through diet, stress reduction, and exercise.
Many foods have the power to reduce inflammation, and wine is thought to be one of them.
Studies suggest that a compound called resveratrol in wine has anti-inflammatory properties and may benefit health (11Trusted Source).
A 2021 trial study of coronary heart disease patients found that low to moderate wine consumption lowered their inflammation (12Trusted Source).
Meanwhile, a 2018 study determined that moderate alcohol consumption helped prevent inflammation from rheumatoid arthritis, though it didnt affect the severity of already-existing inflammation (13Trusted Source).
May promote longevity. Studies have found that drinking moderate amounts of wine as part of a healthy diet is linked with increased longevity (22Trusted Source, 23Trusted Source).
May promote healthy gut bacteria. Recent studies have even suggested that red wine may promote the growth of beneficial gut bacteria, which may improve metabolic syndrome markers in people with obesity (23Trusted Source, 24Trusted Source).
[https://www.healthline.com/nutrition/benefits-of-wine#healthiest-type]
ดังนั้น ในเมื่อผมค้นคำพื้น ๆ แล้วผลส่วนใหญ่บอกว่า ไม่ส่งผล หรือ ส่งผลดี ผมเลยแนะนำเพื่อนสมาชิก และ ผมก็ดื่มเอง ครับ
ผมขอย้ำนะครับ ไวน์แดง แบ่งดื่มอย่างต่ำสามครั้ง สัปดาห์ไม่เกินขวด
